Cortical afferents onto the nucleus Reticularis thalami promote plasticity of low-threshold excitability through GluN2C-NMDARs
نویسندگان
چکیده
منابع مشابه
Somatostatin-like immunoreactivity characterizes neurons of the nucleus reticularis thalami in the cat and monkey.
This report presents immunohistochemical evidence for the occurrence of a somatostatin-related peptide in neurons of the thalamic reticular nucleus, a nucleus known to modulate thalamic activity by y-aminobutyric acid (GABA)-mediated inhibition. In eight cats and kittens and one rhesus monkey, sections through the nucleus reticularis thalami and adjoining regions of the thalamus, subthalamus, a...
متن کاملA model of the electrophysiological properties of nucleus reticularis thalami neurons.
A model of the electrophysiological properties of rodent nucleus reticularis thalami (NRT) neurons of the dorsal lateral thalamus was developed using Hodgkin-Huxley style equations. The model incorporated voltage-dependent rate constants and kinetics obtained from recent voltage-clamp experiments in vitro. The intrinsic electroresponsivity of the model cell was found to be similar to several em...
متن کاملInhibition of NMDARs in the Nucleus Reticularis of the Thalamus Produces Delta Frequency Bursting
Injection of NMDAR antagonist into the thalamus can produce delta frequency EEG oscillations in the thalamocortical system. It is surprising that an antagonist of an excitatory neurotransmitter should trigger such activity, and the mechanism is unknown. One hypothesis is that the antagonist blocks excitation of GABAergic cells, thus producing disinhibition. To test this hypothesis, we investiga...
متن کاملExpression of a functional hyperpolarization-activated current (Ih) in the mouse nucleus reticularis thalami.
The GABAergic neurons of the nucleus reticularis thalami (nRT) express the type 2 hyperpolarization-activated cAMP-sensitive (HCN2) subunit mRNA, but surprisingly, they were reported to lack the hyperpolarization-activated (Ih) current carried by this subunit. Using the voltage-clamp recordings in the thalamocortical slice preparation of the newborn and juvenile mice (P6-P23), we demonstrate th...
متن کاملMechanisms of oscillatory activity in guinea-pig nucleus reticularis thalami in vitro: a mammalian pacemaker.
1. The ionic mechanisms of rhythmic burst firing and single spike, tonic discharge were investigated with extracellular and intracellular recordings of single neurones in the guinea-pig nucleus reticularis thalami (NRT) maintained as a slice in vitro. 2. Activation of cortical/thalamic afferents to NRT neurones resulted in a short latency burst of action potentials which could be followed by a ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/s41598-017-12552-8